Clear and readable for the average reader – yet comprehensive enough for the professional – this reliable reference addresses the effects of high-use, high-abuse drugs in America in a timely and straightforward fashion. Reflects up-to-date research throughout, including coverage of street, over-the- counter, and prescriptive drugs. Highlights the World Wide Web as a growing primary source of drug information. Extensively revises coverage of drug discovery, including major additional information on proteomics, and pharmacogenomics; and highlights the importance of these topics in the context of personalized drug treatment. For professionals in health and drug education, criminal justice, sociology, biology, and chemistry.