Design and Development of Novel Drugs and Vaccines: Principles and Protocols

Bourla Albert

Bogner, William C

Hongmao, Sun

Chowdhury, P R

<p><i>From Globular Proteins to Amyloids</i> proposes a model and mechanism for explaining protein misfolding. Concepts presented are based on a model originally intended to show how proteins attain their native conformations. This model is quantitative in nature and founded upon arguments derived from information theory. It facilitates prediction and simulation of the amyloid fibrillation process, also identifying the progressive changes that occur in native proteins that lead to the emergence of amyloid aggregations.</p>

<p><i>Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics</i> provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book.</p>