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Ras: Past, Present, and Future: Volume 153

Ras: Past, Present, and Future: Volume 153

No customer reviews yet ISBN 9780128244852 Academic Press

Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once "undruggable" RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers.

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BrandAcademic Press
Pub dateFeb 4, 2022
ISBN-100128244852
ISBN-139780128244852
LanguageEnglish
Dimensions9.25 × 1 × 6.25 in
Weight2 lb
Last updated 2026-09-08 12:31
$197.81
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