Patient-centered measurement is the idea that patient perspectives on, for instance, physical functioning or quality of life, should play an evidentiary role in determining how effective a drug is taken to be, the degree to which a hospital provides good quality care or whether a particular intervention should be funded by an insurer. Patient-centered measurement treats patient perspectives on par with more traditional metrics such as mortality, morbidity, and safety. But how can measurement, which relies on standardization, represent patient perspectives, which, if not idiosyncratic, are at least various and changeable? Leah M. McClimans investigates the history and philosophy of patient-centered measurement, examining the use and role of patient questionnaires, and explores how patient-centered measurement sits within the contemporary preoccupation with evidence-based medicine.