Lipoxygenases and Their Metabolites: Biological Functions

Preface; S. Nigam, C.R. Pace-Asciak. Introductory Remarks: Historical Roots and Contemporary Aspects of Lipoxygenase Research; T. Schewe, et al. Part I: Enzymology, Molecular Biology, and Biological Functions of Mammalian Lipoxygenases. Mammalian 15-Lipoxygenases: Enzymatic Properties and Biological Implications; H. Kühn, S. Borngräber. Molecular Cloning of a Second Human 15S-Lipoxygenase and Its Murine Homologue, and 8S-Lipoxygenase: Their Relationship to Other Mammalian Lipoxygenases; A.R. Brash, et al. Arachidonate 12-Lipoxygenase Isozymes; S. Yamamoto, et al. Expression of Leukocyte-Type-12-Lipoxygenase and Reticulocyte-Type 15-Lipoxygenase in Rabbits; B.-J. Thiele, et al Lipoxygenase Gene Disruption Studies- Status and Applications; E.N. Johnson, et al. Part II: Metabolic Regulation of Lipoxygenases: Lipoxygenase Inhibitors. The Release of Polyunsaturated Fatty Acids and Their Lipoxygenation in the Brain; Hee-Yong Kim, et al. Biological Relevance of the 12-Lipoxygenase Pathway for Platelet and Lymphocyte Functions; M. Lagarde, et al. Effect of 15-HETE on the 5-Lipoxygenase Pathway in Neutrophils: Genuine Inhibitor or Alternative Substrate? T. Schewe, et al. Adenosine: An Endogenous Inhibitor of Arachidonic Acid Release and Leukotriene Biosynthesis in Human Neutrophils; E. Krump, P. Borgeat. Pharmacological Aspects of 5-Lipoxygenase Inhibition; R. Müller-Peddinghaus. Part III: Products of the Lipoxygenase Pathways and their Receptors. The Hepoxilins: A Review; C.R. Pace-Asciak, et al. Aspirin-Triggered 15-epi-Lipoxin A4 and Stable Analogs on Lipoxin A4 are Potent Inhibitors of Acute Inflammation: Receptors and Pathways; C.N. Serhan, et al. Modulation of LTB4 Receptor inT-Lymphocytes by Lipoxin A4 (LXA4) and Its Role in Delayed-Type Hypersensitivity; King-Teh Lin, et al. Receptors for Cysteinyl-Leukotrienes in Human Cells; S. Nicosia, et al. Cysteinyl-Leukotrienes and the Human Lung; I. Gorenne, et al. 12(S)-HETE in Cancer Metastasis; Keqin Tang, K.V. Honn. A 12(S)-HETE Receptor in Lewis Lung Carcinoma Cells; H. Herbertsson, et al. Fatty Acids, Eicosanoids, and Hypolipidemic Agents Regulate Gene Expression Through Direct Binding to Peroxisome Proliferator-Activated Receptors; W. Wahli, et al. Biogenesis and Biological Functions of Marine Algal Oxylipins; W.H. Gerwick, et al. Index.