Hepatocellular Carcinoma in Adults and Children, an Issue of Clinics in Liver Disease: Volume 19-2

Larson, Anne M

Pawlik, Timothy M

Herrera, Jorge

Friedman, Lawrence S

In this issue of Clinics in Liver Disease, guest editor Dr. David Bernstein brings his considerable expertise to the topic of The Liver and Renal Disease. The presence of liver disease in patients with chronic renal disease makes the management of both conditions more challenging. In this issue, top experts in the field address many aspects of the treatment and management of these co-existing conditions.<ul> <li> <p>Contains 13 relevant, practice-oriented topics including hyponatremia in cirrhosis&#x3b; pathophysiology of hepatorenal syndrome&#x3b; definitions, diagnosis, and management of hepatorenal syndrome&#x3b; renal replacement therapy in patients with acute liver failure and end-stage cirrhosis awaiting liver transplant&#x3b; simultaneous liver/kidney transplantation&#x3b; and more. </p></li> <li> <p>Provides in-depth clinical reviews on the liver and renal disease, offering actionable insights for clinical practice. </p></li> <li> <p>Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews. </p></li></ul>

In this issue of Clinics in Liver Disease, guest editor Dr. Nikolaos T. Pyrsopoulos brings his considerable expertise to the topic of Acute-on-Chronic Liver Failure. Recent studies indicate that as many as one in four patients with cirrhosis develop acute-on-chronic liver failure (ACLF) and 25% die within one month. This issue, the first devoted to this topic, provides thorough coverage of critical clinical interventions, including diagnosis, treatment, and management. It also focuses on early recognition of ACLF, which is important for the initiation of aggressive management and ultimately, saving lives.<ul> <li> <p>Contains 17 practice-oriented topics including ACLF: mechanisms of disease and multisystemic involvement&#x3b; the clinical spectrum and manifestations of ACLF&#x3b; management of ACLF&#x3b; maximizing the donor potential for patients with ACLF Listed for Liver Transplant&#x3b; future approaches and therapeutic modalities for ACLF&#x3b; and more. </p></li> <li> <p>Provides in-depth clinical reviews of acute-on-chronic liver failure, offering actionable insights for clinical practice. </p></li> <li> <p>Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews. </p></li></ul>