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This issue of the Psychiatric Clinics, edited by Dr. Peter F. Buckley, examines advances and current management in the treatment of Schizophrenia. The topics covered in this issue include, but are not limited to: Duration of Untreated Psychosis (DUP) and Longitudinal Perspectives on DUP; Neuroinflammation and Schizophrenia; Emerging Treatments for Schizophrenia; Treatment-Resistant Schizophrenia; Comorbidities and Schizophrenia; Recovery from Schizophrenia; and the latest in schizophrenia research.