Current Topics in Nonclinical Drug Development: Volume 2

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases. <p>This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins. </p><br><p><i>Here neurologists and other biomedical researchers explain in some detail how PAKs -- particularly the oncogenic kinases PAK1 and PAK4 and their blockers -- may control various aspects of life and health, and how mammalian PAKs have functionally evolved from their ancestral origins in unicellular organisms such as yeast and amoebas through a series of mutations over millions of years.--</i><b><i>Reference and Research Book News, </i> August 2013</b></p><br>

Liu, Guangxu

Mahajan, Pooja

Davis, Frederick Rowe

<p>Filled with practical guidance on how to conduct selenium risk assessments in the aquatic environment, this book offers the latest information on assessment techniques, gives the current state of contamination in industrialized countries, and raises awareness for developing nations. Written by leading experts, it describes best practices for designing experiments to collect information on aquatic effects and trophic transfer of selenium for risk assessments, presents numerous case studies both US and international, and gives insight as to how current and future ecosystems may or may not be affected.</p>

Singh, Akhilesh Vikram