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In this issue of Critical Care Clinics, guest editors Drs. Philip Yang and Annette Esper bring their considerable expertise to the topic of Diagnosis and Management of Acute Respiratory Failure. Top experts in the field cover invasive mechanical ventilation; pharmacologic treatments in ARF; fluid management in ARF; management of ventilator dyssychrony; identification and routine management of ARDS; adjunctive management in ARF and ARDS; and much more.