The book covers the central concerns of Washington's administration: a complex tangle of war debts; the organization of the Bank of the United States; geographical and social factionalism; the emergence of strong national partisan politics; adjustments in federal-state relations; the effort to remain neutral in the face of European tumult; the opening of the Mississippi River; and the removal of the threat of Indians and British in the Northwest Territory. McDonald also describes the rivalry between Washington's two most important department heads, Thomas Jefferson and Alexander Hamilton.