Surrounded by his children, who all seem to be going through life crises involving sex, drugs, and violence; his wife, Karla, who is wrestling with her own demons; and friends like Sonny, who seem to be dying, Duane can't seem to make sense of his life anymore. He gradually makes his way through a protracted end-of-life crisis of which he is finally cured by reading Proust's Remembrance of Things Past, a combination of penance, and prescription from Dr. Carmichael that somehow works.
Duane's Depressed is the work of a powerful, mature artist, with a deep understanding of the human condition, a profound ability to write about small-town life, and perhaps the surest touch of any American novelist for the tangled feelings that bind and separate men and women.