Sars-Cov-2 Spike Protein Convergent Evolution: Impact of Virus Variants on Efficacy of Covid-19 Ther

Why the Spike protein is relevant for COVID19 therapeutics

Whole genome mutation rates

Phylogenetic systems

Mechanism of immune escape: single nucleotide mutations, insertion/deletions, and recombination. Spike protein mutations detected in currently circulating strains.

B.1.1.298

B.1.1.7 (alpha)

B.1.351 (beta)

B.1.1.28- and B.1.1.33-derived Brazilian variants (including gamma and zeta)

B.1.525 (eta)

B.1.526 (iota)

B.1.427/B.1.429 (epsilon)

B.1.617-derived variants (including kappa and delta)

B.1.617.1

Delta VOC

C.37 (lambda)

Other variants under monitoring (VUM)

Which strain will finally become dominant?

SARS-CoV-2 variants characterization

Predicting the functional consequences of mutations

Efficacy of vaccines and monoclonal antibodies against SARS-CoV-2 variants

Selective pressures exerted by antibody-based therapeutics